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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1586096
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pcmtd1
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pcmtd1decreases methylationISOPCMTD1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of PCMTD1 5' UTRPMID:27901495
Pcmtd1increases expressionISOPcmtd1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of PCMTD1 mRNAPMID:22228805
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