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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1565738
Species: Rattus norvegicus
RGD Object: Gene
Symbol: N4bp2
Name: NEDD4 binding protein 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
N4bp2decreases expressionISON4BP2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of N4BP2 mRNAPMID:20106945 PMID:32234424
N4bp2decreases expressionISON4bp2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of N4BP2 mRNAPMID:22228805
N4bp2increases methylationISON4BP2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of N4BP2 promoterPMID:27901495
N4bp2increases methylationISON4bp2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of N4BP2 exon; Benzo(a)pyrene results in increased methylation of N4BP2 intronPMID:27901495
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