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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564397
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hs6st2
Name: heparan sulfate 6-O-sulfotransferase 2
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hs6st2affects expressionISOHs6st2 (Mus musculus)6480464CTDValproic Acid affects the expression of HS6ST2 mRNAPMID:17963808
Hs6st2affects expressionISOHS6ST2 (Homo sapiens)6480464CTDValproic Acid affects the expression of HS6ST2 mRNAPMID:25979313
Hs6st2increases expressionISOHS6ST2 (Homo sapiens)6480464CTDValproic Acid results in increased expression of HS6ST2 mRNAPMID:23179753 PMID:24383497 PMID:24935251 PMID:27188386
Hs6st2increases methylationISOHS6ST2 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of HS6ST2 genePMID:29154799
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