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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1563084
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tbc1d8b
Name: TBC1 domain family member 8B
Acc ID: CHEBI:144400
Term: dinophysistoxin 1
Definition: A ketal that is a marine toxin structurally related to okadaic acid. Produced by dinoflagellates it is known to accumulate in shellfish and cause diarrhoeic shellfish poisoning. It is an inhibitor of serine/threonine protein phosphatases 1 (PP1) and PP2A and has been shown to promote cancer cell growth in tumour cell lines and animal models.
Chemical ID: MESH:C051904
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tbc1d8bdecreases expressionISOTBC1D8B (Homo sapiens)6480464CTDdinophysistoxin 1 results in decreased expression of TBC1D8B mRNAPMID:28939011
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