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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1562047
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cks2
Name: CDC28 protein kinase regulatory subunit 2
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cks2decreases expressionISOCKS2 (Homo sapiens)6480464CTDFluorouracil results in decreased expression of CKS2 mRNAPMID:17374387
Cks2decreases expressionISOCks2 (Mus musculus)6480464CTDFluorouracil results in decreased expression of CKS2 mRNAPMID:19272435
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