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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1561817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnik
Name: TRAF2 and NCK interacting kinase
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnikincreases expressionISOTNIK (Homo sapiens)6480464CTDvorinostat results in increased expression of TNIK mRNAPMID:26272509 PMID:27188386
Tnikmultiple interactionsISOTNIK (Homo sapiens)6480464CTD[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNAPMID:27188386
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