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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1559642
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tfe3
Name: transcription factor binding to IGHM enhancer 3
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tfe3affects localizationISOTfe3 (Mus musculus)6480464CTDCadmium Chloride affects the localization of TFE3 proteinPMID:30030080
Tfe3multiple interactionsISOTfe3 (Mus musculus)6480464CTDTFE3 protein inhibits the reaction [Cadmium Chloride affects the localization of CTSB protein]; TFE3 protein inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]; TFE3 protein inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; TFE3 protein inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]PMID:30030080
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