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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558382
Species: Mus musculus
RGD Object: Gene
Symbol: Relb
Name: avian reticuloendotheliosis viral (v-rel) oncogene related B
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relbincreases expressionEXP 6480464CTDCisplatin results in increased expression of RELB mRNAPMID:26546572
Relbmultiple interactionsEXP 6480464CTD[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of ADH7 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of AK3 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of ANK3 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of ASPG mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of CAMK2D mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of CAR5B mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of CASP1 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of CASP12 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of CLDN1 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of COL4A5 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of COL6A2 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of CYP39A1 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of CYP3A13 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of FBLN2 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of FRK mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of FRMD4B mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of GBE1 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of HACD4 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of HSD17B11 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of IL1RN mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of KRT12 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of LOXL3 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of LRP2 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of MGST2 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of MME mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of MYO6 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of NT5C2 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of OXCT1 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of P3H2 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of PCCA mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of PHKB mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of SEMA3C mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of SLC22A4 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of SPIB mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of SPRR1A mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of TRIM2 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of UBD mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of ARHGEF3 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of CD83 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of COL4A1 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of COL4A2 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of CSTF3 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of CTSH mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of DENND2C mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of ELOVL4 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of EPHB3 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of FUBP1 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of GJB2 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of HEY2 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of KCNQ1OT1 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of LCORL mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of LRATD2 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of LUC7L2 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of NIPAL1 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of PSRC1 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of PTP4A3 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of RAB14 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of RAP1A mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of RHPN1 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of SEC14L2 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of STBD1 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of TMTC3 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of TRP53I11 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of TRPC1 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of TTC9 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of UBXN2B mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of ZFP37 mRNA; [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of ZFR mRNA; [Cisplatin co-treated with RELB mutant form] results in decreased expression of ANGPTL4 mRNA; [Cisplatin co-treated with RELB mutant form] results in decreased expression of APOBEC1 mRNA; [Cisplatin co-treated with RELB mutant form] results in decreased expression of IL15RA mRNA; [Cisplatin co-treated with RELB mutant form] results in decreased expression of LAYN mRNA; [Cisplatin co-treated with RELB mutant form] results in decreased expression of MAF mRNA; [Cisplatin co-treated with RELB mutant form] results in decreased expression of MAP3K6 mRNA; [Cisplatin co-treated with RELB mutant form] results in decreased expression of NRIP2 mRNA; [Cisplatin co-treated with RELB mutant form] results in decreased expression of PLTP mRNA; [Cisplatin co-treated with RELB mutant form] results in decreased expression of RGS3 mRNA; [Cisplatin co-treated with RELB mutant form] results in decreased expression of SUCLG2 mRNA; [Cisplatin co-treated with RELB mutant form] results in increased expression of ARAP2 mRNA; [Cisplatin co-treated with RELB mutant form] results in increased expression of CDC42BPG mRNA; [Cisplatin co-treated with RELB mutant form] results in increased expression of CELSR2 mRNA; [Cisplatin co-treated with RELB mutant form] results in increased expression of CSF1 mRNA; [Cisplatin co-treated with RELB mutant form] results in increased expression of GRB10 mRNA; [Cisplatin co-treated with RELB mutant form] results in increased expression of KLF7 mRNA; [Cisplatin co-treated with RELB mutant form] results in increased expression of KLHL23 mRNA; [Cisplatin co-treated with RELB mutant form] results in increased expression of NDRG4 mRNA; [Cisplatin co-treated with RELB mutant form] results in increased expression of NKAIN1 mRNA; [Cisplatin co-treated with RELB mutant form] results in increased expression of POLR3GL mRNAPMID:23625948
Relbincreases expressionISORELB (Homo sapiens)6480464CTDCisplatin results in increased expression of RELB mRNAPMID:27594783
Relbmultiple interactionsISORELB (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in decreased expression of RELB mRNAPMID:27392435
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