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GENE - TERM ANNOTATION REPORT

RGD ID: 1557760
Species: Mus musculus
RGD Object: Gene
Symbol: Vps9d1
Name: VPS9 domain containing 1
Acc ID: GO:0005085
Term: guanyl-nucleotide exchange factor activity
Definition: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
Definition Source(s): GOC:kd, GOC:mah, PMID:23303910, PMID:27218782
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vps9d1enablesIBAPANTHER:PTN000559490 or UniProtKB:Q9UJ41 or UniProtKB:Q10NQ3 or FB:FBgn0262937 or MGI:1913941 or TAIR:locus:2092211 or UniProtKB:Q8TB24 or SGD:S000005991 or SGD:S000004563 or UniProtKB:Q14C86 or MGI:24440242290270GO_Central GO_REF:0000033
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