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GENE - TERM ANNOTATION REPORT

RGD ID: 1557355
Species: Mus musculus
RGD Object: Gene
Symbol: Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Acc ID: DOID:9119
Term: acute myeloid leukemia
Definition: A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. (DO)
Definition Source(s): http://cancergenome.nih.gov/cancersselected/acutemyeloidleukemia "DO" "DO", http://en.wikipedia.org/wiki/Acute_myeloid_leukemia "DO" "DO", http://www.cancer.gov/dictionary?cdrid=44363 "DO" "DO", https://www.cancer.org/cancer/acute-myeloid-leukemia/detection-diagnosis-staging/how-classified.html "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Idh2disease_progressionISOIDH2 (Homo sapiens)11522718RGDDNA:mutation:cds:p.R172(human) 
Idh2disease_progressionISOIDH2 (Homo sapiens)11522721RGDDNA:mutation:cds:p.R140 (human) 
Idh2 ISOIDH2 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:25324972 PMID:27992414
Idh2 ISOIDH2 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia | ClinVar Annotator: match by term: Acute myeloid leukemia, adultPMID:20171147 PMID:20847235 PMID:20946881 PMID:21250968 PMID:21596855 PMID:21647154 PMID:21889589 PMID:21997850 PMID:22160010 PMID:22397365 PMID:22417203 PMID:22616558 PMID:22898539 PMID:23558173 PMID:23815907 PMID:23949315 PMID:24049096 PMID:24589777 PMID:24606448 PMID:25157968 PMID:25326635 PMID:25398939 PMID:25741868 PMID:26619011 PMID:28166811 PMID:28492532 PMID:34641967
Idh2 ISOIDH2 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia | ClinVar Annotator: match by term: Acute myeloid leukemia, adultPMID:20171147 PMID:20847235 PMID:20946881 PMID:21250968 PMID:21596855 PMID:21889589 PMID:21997850 PMID:22160010 PMID:22397365 PMID:22417203 PMID:22616558 PMID:22898539 PMID:23558173 PMID:23815907 PMID:23949315 PMID:24049096 PMID:24606448 PMID:25157968 PMID:25326635 PMID:25741868 PMID:26619011 PMID:28492532
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