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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551913
Species: Mus musculus
RGD Object: Gene
Symbol: Prkd1
Name: protein kinase D1
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkd1increases phosphorylationISOPrkd1 (Rattus norvegicus)243065275RGDPhenylephrine increases phosphorylation of Prkd1 protein in neonatal ventricular myocytes 
Prkd1affects localizationEXP 6480464CTDPhenylephrine affects the localization of PRKD1 proteinPMID:19124542
Prkd1increases activityEXP 6480464CTDPhenylephrine results in increased activity of PRKD1 proteinPMID:19124542
Prkd1multiple interactionsEXP 6480464CTD[Phenylephrine results in increased activity of PRKD1 protein] which affects the localization of HDAC5 proteinPMID:19124542
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