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REFERENCE - CHEMICAL INTERACTIONS REPORT

RGD ID: 15036815
Species: All species
RGD Object: Reference
Acc ID: CHEBI:76674
Term: phosphorothioate oligonucleotide
Definition: An oligonucleotide in which one of the non-bridging oxygens in each phosphodiester linkage has been replaced by sulfur. The main application of phosphorothioate linkages in an oligonucleotide is to protect the oligonucleotide from nuclease degradation.
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh2decreases expressionEXP 15036815RGDphosphorothioate oligonucleotide decreased mRNA and activity of ALDH2 in rat liver 
ALDH2decreases expressionISOAldh2 (Rattus norvegicus)15036815RGDphosphorothioate oligonucleotide decreased mRNA and activity of ALDH2 in rat liver 
Aldh2decreases expressionISOAldh2 (Rattus norvegicus)15036815RGDphosphorothioate oligonucleotide decreased mRNA and activity of ALDH2 in rat liver 
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