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GENE - TERM ANNOTATION REPORT

RGD ID: 14235746
Species: Sus scrofa
RGD Object: Gene
Symbol: FAF1
Name: Fas associated factor 1
Acc ID: GO:0036503
Term: ERAD pathway
Definition: The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
Definition Source(s): GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FAF1involved_inIBAPANTHER:PTN000595050 or SGD:S000004475 or UniProtKB:O00124 or UniProtKB:Q96CS3150520179GO_Central GO_REF:0000033
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