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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14161060
Species: Sus scrofa
RGD Object: Gene
Symbol: SOD2
Name: superoxide dismutase 2
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD2decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of SOD2 mRNAPMID:33626375
SOD2decreases response to substanceEXP 6480464CTDSOD2 results in decreased susceptibility to Cadmium ChloridePMID:18086661
SOD2multiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SOD2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SOD2 mRNA; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; SOD2 inhibits the reaction [Cadmium Chloride results in increased splicing of XBP1 mRNA]PMID:18086661 PMID:33493553 PMID:34416349
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