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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14131615
Species: Sus scrofa
RGD Object: Gene
Symbol: NLRP3
Name: NLR family pyrin domain containing 3
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NLRP3increases expressionEXP 6480464CTDZearalenone results in increased expression of NLRP3 mRNA; Zearalenone results in increased expression of NLRP3 proteinPMID:30270565
NLRP3multiple interactionsEXP 6480464CTD[Dextran Sulfate co-treated with Zearalenone] results in increased expression of NLRP3 mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of NLRP3 protein; Dextran Sulfate inhibits the reaction [Zearalenone results in increased expression of NLRP3 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 protein]PMID:30270565
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