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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14007049
Species: Sus scrofa
RGD Object: Gene
Symbol: MAPK1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK1multiple interactionsEXP 6480464CTD[pyrazolanthrone co-treated with etoxazole] results in increased phosphorylation of MAPK1 protein; pyrazolanthrone inhibits the reaction [Ivermectin results in decreased phosphorylation of MAPK1 protein]PMID:31400776 PMID:31744678
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