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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359580
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atg5
Name: autophagy related 5
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atg5increases expressionEXP 6480464CTDTunicamycin results in increased expression of ATG5 mRNA; Tunicamycin results in increased expression of ATG5 proteinPMID:37654027
Atg5increases expressionISOATG5 (Homo sapiens)6480464CTDTunicamycin results in increased expression of ATG5 proteinPMID:36640941
Atg5increases expressionISOAtg5 (Mus musculus)6480464CTDTunicamycin results in increased expression of ATG5 mRNAPMID:29793971
Atg5increases response to substanceISOAtg5 (Mus musculus)6480464CTDATG5 protein mutant form results in increased susceptibility to TunicamycinPMID:29793971
Atg5multiple interactionsISOATG5 (Homo sapiens)6480464CTDCurcumin inhibits the reaction [Tunicamycin results in increased expression of ATG5 protein]PMID:36640941
Atg5multiple interactionsISOAtg5 (Mus musculus)6480464CTD[ATG5 protein mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of ATF4 mRNA; [ATG5 protein mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of DDIT3 mRNA; [ATG5 protein mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of DNAJB9 mRNA; [ATG5 protein mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of EIF2AK3 mRNA; [ATG5 protein mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of HSPA5 mRNA; [ATG5 protein mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of PPP1R15A mRNA; [ATG5 protein mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of SQSTM1 protein; [ATG5 protein mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of XBP1 mRNA; ATG5 protein mutant form inhibits the reaction [Tunicamycin results in increased lipidation of MAP1LC3B protein]PMID:29793971
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