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GENE - TERM ANNOTATION REPORT

RGD ID: 1359423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Isyna1
Name: inositol-3-phosphate synthase 1
Acc ID: GO:0004512
Term: inositol-3-phosphate synthase activity
Definition: Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form.
Definition Source(s): EC:5.5.1.4, RHEA:10716
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Isyna1enablesISOISYNA1 (Homo sapiens)1624291RGDUniProtKB:P11986 PMID:23902760

PMID:23902760
Isyna1enablesIBACGD:CAL0000189325 or FB:FBgn0025885 or PANTHER:PTN000161823 or SGD:S000003689 or TAIR:locus:2060364 or TAIR:locus:2135297 or TAIR:locus:2184153 or UniProtKB:Q8A7J8 or UniProtKB:Q8I3Y8 or UniProtKB:Q9NPH2 or dictyBase:DDB_G02855051600115GO_CentralGO_REF:0000033

GO_REF:0000033
Isyna1NOT|enablesIDA 153298950UniProtPMID:19188364

 
Isyna1enablesIDA 153298936UniProtPMID:885873

 
Isyna1enablesIDA 153298945UniProtPMID:23504145

 
Isyna1enablesIDA 153298950UniProtPMID:19188364

 
Isyna1enablesIDA 153298956UniProtPMID:6773943

 
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