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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350137
Species: Homo sapiens
RGD Object: Gene
Symbol: MEG8
Name: maternally expressed 8, small nucleolar RNA host gene
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MEG8increases expressionEXP 6480464CTDPhenobarbital results in increased expression of RIAN mRNAPMID:28541575
MEG8increases expressionISORian (Mus musculus)6480464CTDPhenobarbital results in increased expression of RIAN mRNAPMID:23091169 PMID:28541575
MEG8multiple interactionsISORian (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of RIAN mRNA; CTNNB1 protein affects the reaction [Phenobarbital results in increased expression of RIAN mRNA]; NR1I2 protein affects the reaction [Phenobarbital results in increased expression of RIAN mRNA]; NR1I3 protein affects the reaction [Phenobarbital results in increased expression of RIAN mRNA]PMID:23091169 PMID:24535843
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