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GENE - TERM ANNOTATION REPORT

RGD ID: 1350018
Species: Homo sapiens
RGD Object: Gene
Symbol: UGT1A1
Name: UDP glucuronosyltransferase family 1 member A1
Acc ID: DOID:9004486
Term: Drug-induced Neutropenia
Definition: A significant reduction in NEUTROPHIL count associated with CHEMOTHERAPY or other drug treatment.
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
UGT1A1susceptibilityIAGP 10768826RGDassociated with neoplasms;DNA:polymorphism, repeat:promoter:-3156G>A, TA (human) 
UGT1A1susceptibilityIAGP 10768867RGDassociated with Genital Neoplasms, Female;DNA:polymorphisms: : 
UGT1A1susceptibilityIAGP 10769334RGDassociated with Adenocarcinoma, Colorectal;DNA:repeat:promoter:(TA) (rs8175347) 
UGT1A1susceptibilityIAGP 10769336RGDassociated with Esophageal Neoplasms,Stomach Neoplasm;DNA:repeat:promoter:(TA) 
UGT1A1treatmentIAGP 10769339RGDassociated with Carcinoma, Non-Small-Cell Lung; DNA:repeat:promoter:(TA) 
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