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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347299
Species: Homo sapiens
RGD Object: Gene
Symbol: SMAD2
Name: SMAD family member 2
Acc ID: CHEBI:28946
Term: theobromine
Definition: A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Chemical ID: MESH:D013805
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SMAD2treatmentISOSmad2 (Rattus norvegicus)127229954RGD[Theobromine co-treated with Theanine] inhibits the reaction [1,2-dimethylhydrazine decreases expression and phosphorylation of Smad2 mRNA and protein, respectively in the colon] 
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