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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345409
Species: Homo sapiens
RGD Object: Gene
Symbol: HMGA1
Name: high mobility group AT-hook 1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMGA1decreases expressionEXP 6480464CTDProgesterone results in decreased expression of HMGA1 mRNAPMID:17404688 PMID:20660070
HMGA1multiple interactionsEXP 6480464CTD4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of HMGA1 mRNA]; [Estradiol co-treated with Progesterone] results in decreased expression of HMGA1 mRNA; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of HMGA1 mRNA]; pepstatin inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of HMGA1 mRNA]PMID:20660070
HMGA1decreases expressionISOHmga1 (Mus musculus)6480464CTDProgesterone results in decreased expression of HMGA1 mRNAPMID:22238285
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