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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:30501
Term: beryllium atom
Definition: Alkaline earth metal atom with atomic number 4.
Chemical ID: MESH:D001608
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFincreases expressionEXP 6480464CTDBeryllium results in increased expression of TNF mRNAPMID:8629860
TNFincreases response to substanceEXP 6480464CTDTNF promoter polymorphism results in increased susceptibility to BerylliumPMID:15127972
TNFincreases secretionEXP 6480464CTDBeryllium results in increased secretion of TNF proteinPMID:12449171
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