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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332276
Species: Mus musculus
RGD Object: Gene
Symbol: P2ry14
Name: purinergic receptor P2Y, G-protein coupled, 14
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
P2ry14decreases expressionEXP 6480464CTDEstradiol results in decreased expression of P2RY14 mRNAPMID:39298647
P2ry14increases expressionEXP 6480464CTDEstradiol results in increased expression of P2RY14 mRNAPMID:18367319
P2ry14multiple interactionsEXP 6480464CTDbazedoxifene inhibits the reaction [Estradiol results in increased expression of P2RY14 mRNA]; Lasofoxifene inhibits the reaction [Estradiol results in increased expression of P2RY14 mRNA]; Progesterone inhibits the reaction [Estradiol results in increased expression of P2RY14 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of P2RY14 mRNA]PMID:18367319
P2ry14multiple interactionsISOP2RY14 (Homo sapiens)6480464CTD[Estradiol co-treated with Progesterone] results in increased expression of P2RY14 mRNA; [Progesterone co-treated with Estradiol] results in increased expression of P2RY14 mRNAPMID:17404688 PMID:20660070
P2ry14multiple interactionsISOP2ry14 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of P2RY14 mRNAPMID:26496021
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