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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1322368
Species: Mus musculus
RGD Object: Gene
Symbol: Emx2
Name: empty spiracles homeobox 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Emx2affects methylationEXP 6480464CTDbisphenol A affects the methylation of EMX2 promoterPMID:27334623
Emx2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of EMX2 mRNAPMID:30951980
Emx2increases expressionEXP 6480464CTDbisphenol A results in increased expression of EMX2 mRNAPMID:32156529
Emx2decreases expressionISOEmx2 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of EMX2 mRNAPMID:25181051 PMID:34947998
Emx2decreases methylationISOEMX2 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of EMX2 genePMID:31601247
Emx2increases expressionISOEmx2 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of EMX2 mRNAPMID:21285323
Emx2multiple interactionsISOEMX2 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EMX2 mRNAPMID:28628672
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