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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319788
Species: Mus musculus
RGD Object: Gene
Symbol: Vangl2
Name: VANGL planar cell polarity 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vangl2decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of VANGL2 mRNAPMID:21569818 PMID:22228805
Vangl2decreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of VANGL2 intronPMID:27901495
Vangl2affects methylationISOVANGL2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of VANGL2 3' UTR; Benzo(a)pyrene affects the methylation of VANGL2 5' UTR; Benzo(a)pyrene affects the methylation of VANGL2 intron; Benzo(a)pyrene affects the methylation of VANGL2 promoterPMID:27901495 PMID:30157460
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