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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1316170
Species: Homo sapiens
RGD Object: Gene
Symbol: COL4A1
Name: collagen type IV alpha 1 chain
Acc ID: CHEBI:46557
Term: zoledronic acid
Definition: An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.
Chemical ID: MESH:C088658
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
COL4A1increases expressionISOCol4a1 (Mus musculus)6480464CTDzoledronic acid results in increased expression of COL4A1 mRNAPMID:28871336
COL4A1multiple interactionsISOCol4a1 (Mus musculus)6480464CTDFenofibrate inhibits the reaction [zoledronic acid results in increased expression of COL4A1 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of COL4A1 mRNA]PMID:28871336
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