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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315332
Species: Homo sapiens
RGD Object: Gene
Symbol: USP53
Name: ubiquitin specific peptidase 53
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
USP53affects expressionEXP 6480464CTDFolic Acid affects the expression of USP53 mRNAPMID:17320366
USP53multiple interactionsEXP 6480464CTD[Ethanol co-treated with Folic Acid] results in increased expression of USP53 mRNAPMID:23378141
USP53multiple interactionsISOUsp53 (Mus musculus)6480464CTD[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of USP53 genePMID:20938992
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