Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314850
Species: Mus musculus
RGD Object: Gene
Symbol: Tjp1
Name: tight junction protein 1
Acc ID: CHEBI:9434
Term: telmisartan
Definition: A member of the class of benzimidazoles used widely in the treatment of hypertension.
Chemical ID: MESH:C084178
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tjp1affects localizationISOTJP1 (Homo sapiens)6480464CTDtelmisartan affects the localization of TJP1 proteinPMID:19252288
Tjp1decreases expressionISOTJP1 (Homo sapiens)6480464CTDtelmisartan results in decreased expression of TJP1 mRNA; telmisartan results in decreased expression of TJP1 proteinPMID:19252288
Tjp1multiple interactionsISOTJP1 (Homo sapiens)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan affects the localization of TJP1 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]; wortmannin inhibits the reaction [telmisartan affects the localization of TJP1 protein]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]PMID:19252288
Go Back to source page   Continue to Ontology report