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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314849
Species: Homo sapiens
RGD Object: Gene
Symbol: TJP1
Name: tight junction protein 1
Acc ID: CHEBI:9434
Term: telmisartan
Definition: A member of the class of benzimidazoles used widely in the treatment of hypertension.
Chemical ID: MESH:C084178
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TJP1affects localizationEXP 6480464CTDtelmisartan affects the localization of TJP1 proteinPMID:19252288
TJP1decreases expressionEXP 6480464CTDTelmisartan results in decreased expression of TJP1 mRNA; Telmisartan results in decreased expression of TJP1 proteinPMID:19252288
TJP1multiple interactionsEXP 6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan affects the localization of TJP1 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]; wortmannin inhibits the reaction [telmisartan affects the localization of TJP1 protein]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]PMID:19252288
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