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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1312368
Species: Homo sapiens
RGD Object: Gene
Symbol: MBD2
Name: methyl-CpG binding domain protein 2
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MBD2decreases activityEXP 6480464CTDDecitabine results in decreased activity of MBD2 proteinPMID:19221000
MBD2multiple interactionsEXP 6480464CTD[Decitabine co-treated with trichostatin A] inhibits the reaction [MBD2 protein binds to CLDN3 promoter]; Decitabine inhibits the reaction [MBD2 protein binds to BUB1B promoter]; Decitabine inhibits the reaction [MBD2 protein binds to CLDN3 promoter]PMID:17464181 PMID:17986852
MBD2multiple interactionsISOMbd2 (Rattus norvegicus)6480464CTDDecitabine inhibits the reaction [Dust results in increased expression of MBD2 mRNA]; Decitabine inhibits the reaction [Dust results in increased expression of MBD2 protein]PMID:30815999
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