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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311509
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ercc6
Name: ERCC excision repair 6, chromatin remodeling factor
Acc ID: CHEBI:75399
Term: NU 1025
Definition: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase.
Chemical ID: MESH:C115774
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ercc6affects response to substanceISOERCC6 (Homo sapiens)6480464CTDERCC6 gene mutant form affects the susceptibility to NU 1025PMID:25440059
Ercc6multiple interactionsISOERCC6 (Homo sapiens)6480464CTDNU 1025 inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]PMID:25440059
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