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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mad2l1
Name: mitotic arrest deficient 2 like 1
Acc ID: CHEBI:27656
Term: camptothecin
Definition: A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Chemical ID: MESH:D002166
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mad2l1increases expressionISOMAD2L1 (Homo sapiens)6480464CTDCamptothecin results in increased expression of MAD2L1 mRNA; Camptothecin results in increased expression of MAD2L1 proteinPMID:30885713
Mad2l1multiple interactionsISOMAD2L1 (Homo sapiens)6480464CTDCamptothecin promotes the reaction [MAD2L1 protein binds to CDC20 protein]; CDKN1A protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of and results in increased activity of CDK1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP8 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP9 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]PMID:30885713
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