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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310847
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bag5
Name: BAG cochaperone 5
Acc ID: CHEBI:6121
Term: ketamine
Definition: A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Chemical ID: MESH:D007649
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bag5increases expressionEXP 6480464CTDKetamine results in increased expression of BAG5 mRNA; Ketamine results in increased expression of BAG5 proteinPMID:34670429
Bag5multiple interactionsEXP 6480464CTDBAG5 protein inhibits the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of CASP3 mRNA]]; lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of BAG5 mRNA]; lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of BAG5 protein]; MIR22 affects the reaction [Ketamine results in increased expression of BAG5 mRNA]; MIR22 affects the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of BAG5 protein]]; MIR22 inhibits the reaction [Ketamine results in increased expression of BAG5 protein]PMID:34670429
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