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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310404
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd248
Name: CD248 molecule
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd248decreases expressionISOCD248 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CD248 mRNAPMID:26238291
Cd248decreases expressionISOCd248 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CD248 mRNAPMID:22610609
Cd248decreases methylationISOCD248 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of CD248 exonPMID:27901495
Cd248increases methylationISOCD248 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of CD248 promoterPMID:27901495
Cd248multiple interactionsISOCd248 (Mus musculus)6480464CTD[corannulene co-treated with Benzo(a)pyrene] results in increased expression of CD248 mRNA; Benzo(a)pyrene promotes the reaction [AHR protein binds to CD248 promoter]PMID:19654925 PMID:32417428
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