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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310293
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncor2
Name: nuclear receptor co-repressor 2
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncor2decreases expressionISONCOR2 (Homo sapiens)6480464CTDarsenite results in decreased expression of NCOR2 mRNAPMID:31646340
Ncor2increases expressionISONcor2 (Mus musculus)6480464CTDarsenite results in increased expression of NCOR2 mRNAPMID:18191166
Ncor2multiple interactionsISONCOR2 (Homo sapiens)6480464CTDarsenite inhibits the reaction [Fulvestrant results in increased expression of NCOR2 mRNA]; arsenite inhibits the reaction [G3BP1 protein binds to NCOR2 mRNA]; Fulvestrant inhibits the reaction [arsenite results in decreased expression of NCOR2 mRNA]PMID:31646340 PMID:32406909
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