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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310293
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncor2
Name: nuclear receptor co-repressor 2
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncor2multiple interactionsISONCOR2 (Homo sapiens)6480464CTDLithocholic Acid inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]; Lithocholic Acid inhibits the reaction [VDR protein binds to NCOR2 protein]; Lithocholic Acid promotes the reaction [VDR protein binds to NCOR2 protein]PMID:21917910 PMID:22466564
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