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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309970
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsta4
Name: glutathione S-transferase alpha 4
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsta4decreases expressionEXP 6480464CTDNicotine results in decreased expression of GSTA4 mRNAPMID:9774145
Gsta4increases activityEXP 6480464CTDNicotine results in increased activity of GSTA4 proteinPMID:9774145
Gsta4increases expressionEXP 6480464CTDNicotine results in increased expression of GSTA4 mRNAPMID:9774145
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