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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309691
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Higd2a
Name: HIG1 hypoxia inducible domain family, member 2A
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Higd2amultiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of HIGD2A promoterPMID:23359474
Higd2adecreases expressionISOHigd2a (Mus musculus)6480464CTDDibutyl Phthalate results in decreased expression of HIGD2A mRNAPMID:21266533
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