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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309583
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tfeb
Name: transcription factor EB
Acc ID: CHEBI:67895
Term: corosolic acid
Definition: A triterpenoid that has formula C30H48O4.
Chemical ID: MESH:C113861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tfebincreases response to substanceEXP 6480464CTDTFEB protein results in increased susceptibility to corosolic acidPMID:34296331
Tfebmultiple interactionsEXP 6480464CTDTFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of LAMP2 protein]]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; TFEB protein promotes the reaction [corosolic acid inhibits the reaction [Doxorubicin results in increased expression of SQSTM1 protein]]PMID:34296331
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