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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309544
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Zmynd8
Name: zinc finger, MYND-type containing 8
Acc ID: CHEBI:85990
Term: panobinostat
Definition: A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its lactate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.
Chemical ID: MESH:C496932
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Zmynd8affects expressionISOZMYND8 (Homo sapiens)6480464CTDpanobinostat affects the expression of ZMYND8 mRNAPMID:26733615
Zmynd8multiple interactionsISOZMYND8 (Homo sapiens)6480464CTD(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of ZMYND8 mRNA]; panobinostat promotes the reaction [(+)-JQ1 compound affects the expression of ZMYND8 mRNA]PMID:26733615
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