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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309404
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpr35
Name: G protein-coupled receptor 35
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpr35affects response to substanceISOGPR35 (Homo sapiens)6480464CTDGPR35 protein affects the susceptibility to FluorouracilPMID:15331170
Gpr35increases expressionISOGPR35 (Homo sapiens)6480464CTDFluorouracil results in increased expression of GPR35 mRNAPMID:15331170
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