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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309398
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Klf1
Name: KLF transcription factor 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klf1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of KLF1 mRNAPMID:22298810
Klf1decreases expressionISOKlf1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of KLF1 mRNAPMID:21354282 PMID:37172768
Klf1multiple interactionsISOKlf1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of KLF1 mRNAPMID:19465110
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