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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309306
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdm4
Name: MDM4 regulator of p53
Acc ID: CHEBI:88046
Term: cylindrospermopsin
Definition: A triazaacenaphthylene that is 2,2a,3,4,5,5a,6,7-octahydro-1H-1,8,8b-triazaacenaphthylene which is substituted at positions 3, 4, and 7 by methyl, sulfooxy, and (2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)(hydroxy)methyl groups, respectively (the 2aS,3R,4S,5aS,7R stereoisomer in which the carbon bearing the hydroxy group has R configuration). It is a cyanotoxin produced by several species of freshwater cyanobacteria, such as Aphanizomenon ovalisporum.
Chemical ID: MESH:C089595
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdm4increases expressionISOMDM4 (Homo sapiens)6480464CTDcylindrospermopsin results in increased expression of MDM4 mRNAPMID:24921660
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