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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309306
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdm4
Name: MDM4 regulator of p53
Acc ID: CHEBI:3423
Term: carmustine
Definition: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Chemical ID: MESH:D002330
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdm4decreases response to substanceISOMDM4 (Homo sapiens)6480464CTDMDM4 protein results in decreased susceptibility to CarmustinePMID:20472715
Mdm4multiple interactionsISOMDM4 (Homo sapiens)6480464CTD[Carmustine co-treated with MDM4 protein] results in increased expression of POLH protein; MDM4 protein promotes the reaction [Carmustine affects the localization of H2AX protein]; MDM4 protein promotes the reaction [Carmustine results in increased expression of CDKN1A protein]; MDM4 protein promotes the reaction [Carmustine results in increased expression of TP53 protein]; MDM4 protein promotes the reaction [Carmustine results in increased phosphorylation of H2AX protein]PMID:20472715
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