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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309132
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppp1r3c
Name: protein phosphatase 1, regulatory subunit 3C
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp1r3cdecreases expressionISOPPP1R3C (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PPP1R3C mRNAPMID:21632981 PMID:26238291 PMID:32234424
Ppp1r3cdecreases expressionISOPpp1r3c (Mus musculus)6480464CTDBenzo(a)pyrene metabolite results in decreased expression of PPP1R3C mRNA; Benzo(a)pyrene results in decreased expression of PPP1R3C mRNAPMID:15034205 PMID:15894712 PMID:22228805 PMID:32553695
Ppp1r3cincreases expressionISOPpp1r3c (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of PPP1R3C mRNAPMID:19770486
Ppp1r3cincreases methylationISOPPP1R3C (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PPP1R3C 3' UTR; Benzo(a)pyrene results in increased methylation of PPP1R3C exon; Benzo(a)pyrene results in increased methylation of PPP1R3C promoterPMID:27901495
Ppp1r3cmultiple interactionsISOPpp1r3c (Mus musculus)6480464CTD[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PPP1R3C mRNA; AHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of PPP1R3C mRNA]PMID:15034205 PMID:15894712
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