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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308845
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Reck
Name: reversion-inducing-cysteine-rich protein with kazal motifs
Acc ID: CHEBI:34887
Term: nickel dichloride
Definition: A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Chemical ID: MESH:C022838
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Reckdecreases expressionISORECK (Homo sapiens)6480464CTDnickel chloride results in decreased expression of RECK proteinPMID:26026961
Reckmultiple interactionsISORECK (Homo sapiens)6480464CTD3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [nickel chloride results in decreased expression of RECK protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [nickel chloride results in decreased expression of RECK protein]; [nickel chloride results in increased expression of MIR21 mRNA] which results in decreased expression of RECK protein; RECK protein inhibits the reaction [nickel chloride results in increased expression of EGFR protein]PMID:26026961
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