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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308676
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd3b1
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd3b1decreases expressionEXP 6480464CTDGenistein results in decreased expression of HSD3B1 mRNA; Genistein results in decreased expression of HSD3B1 proteinPMID:25031359
Hsd3b1increases expressionEXP 6480464CTDGenistein results in increased expression of HSD3B1 mRNAPMID:31201582
Hsd3b1multiple interactionsEXP 6480464CTD[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of HSD3B1 mRNA; [Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of HSD3B1 protein; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of HSD3B1 mRNA; [Genistein co-treated with vinclozolin] results in decreased expression of HSD3B1 mRNAPMID:25031359 PMID:28964809 PMID:32827888
Hsd3b1decreases expressionISOHsd3b1 (Mus musculus)6480464CTDGenistein results in decreased expression of HSD3B1 mRNAPMID:24967385 PMID:26792615
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