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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308443
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nkx2-2
Name: NK2 homeobox 2
Acc ID: CHEBI:73755
Term: 1,2-dimethylhydrazine
Definition: A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Chemical ID: MESH:D019813
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nkx2-2decreases expressionISONkx2-2 (Mus musculus)6480464CTD1,2-Dimethylhydrazine results in decreased expression of NKX2-2 mRNAPMID:22206623
Nkx2-2multiple interactionsISONkx2-2 (Mus musculus)6480464CTDFolic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of NKX2-2 mRNA]PMID:22206623
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