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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308369
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Samhd1
Name: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Acc ID: CHEBI:6402
Term: leflunomide
Definition: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Chemical ID: MESH:C045463
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Samhd1decreases expressionISOSAMHD1 (Homo sapiens)6480464CTDleflunomide results in decreased expression of SAMHD1 mRNAPMID:28988120
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